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Glaucoma Market Spotlight 2019: 10-Year Disease Prevalence Forecast, Licensing and Acquisition Deals, Revenue Forecasts – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “Market
Spotlight: Glaucoma”
report has been added to ResearchAndMarkets.com’s
offering.

This Market Spotlight report covers the Glaucoma market, comprising key
pipeline and marketed drugs, clinical trials, upcoming and regulatory
events, patent information, a 10-year disease prevalence forecast, and
licensing and acquisition deals, as well as presenting drug-specific
revenue forecasts

Key Takeaways

  • The author estimates that in 2017, there were 95.5 million prevalent
    cases of glaucoma in adults aged 40 years and older worldwide, and
    forecasts that number to increase to 113.4 million prevalent cases by
    2026.
  • Africa is estimated to have the highest disease prevalence (4.79%),
    while Europe and Oceania have the lowest prevalence (2.93% and 2.97%,
    respectively).
  • The majority of approved drugs in the glaucoma space target beta
    adrenergic receptors or the prostaglandin F receptor. Zioptan and
    Neptazane are the only marketed drugs for glaucoma administered via
    the intraocular/subretinal/subconjunctival and oral routes,
    respectively, with the remainder being topical formulations.
  • The majority of industry-sponsored drugs in active clinical
    development for glaucoma are in Phase II, with only one drug in the
    NDA/BLA phase.
  • While a small number of mid-to-late-stage drugs in the glaucoma space
    are exploring new targets, such as Rho kinase, the established target
    prostaglandin F receptor continues to lead clinical development. The
    largest number of drugs in mid-to-latestage development for glaucoma
    are administered via the intraocular/subretinal/subconjunctival route,
    with the remainder being topical and oral formulations.
  • High-impact upcoming events for drugs in the glaucoma space comprise
    topline Phase II and Phase III trial results, an estimated PDUFA date,
    an expected CHMP opinion, and expected CHMP supplemental filing
    results.
  • The overall likelihood of approval of a Phase I glaucoma asset is
    3.9%, and the average probability a drug advances from Phase III is
    58.3%. Drugs, on average, take 8.9 years from Phase I to approval,
    compared to 8.8 years in the overall ophthalmology space.
  • There were 24 licensing and asset acquisition deals involving glaucoma
    drugs during 2014-18. The largest deal was in 2014, when Merck sold
    Asian rights for five of its glaucoma drugs to Santen for $600m.
  • The clinical trials distribution across Phase I-IV indicates that the
    majority of trials for glaucoma have been in the late phases of
    development, with 59% in Phase III-IV, and 41% in Phase I-II.
  • The US has a substantial lead in the number of glaucoma clinical
    trials globally. Germany leads the major EU markets, while Japan has
    the top spot in Asia.
  • Clinical trial activity in the glaucoma space is dominated by
    completed trials. Novartis has the highest number of completed trials
    for glaucoma, with 156 trials.
  • Novartis leads the industry sponsors with by far the highest number of
    clinical trials for glaucoma, followed by Allergan.

Key Topics Covered:

OVERVIEW

KEY TAKEAWAYS

DISEASE BACKGROUND

Subtypes

TREATMENT

Eye drops

Oral medications

EPIDEMIOLOGY

MARKETED DRUGS

PIPELINE DRUGS

RECENT EVENTS AND ANALYST OPINION

Bimatoprost Sustained Release for Glaucoma (January 7, 2019)

Bimatoprost Sustained Release for Glaucoma (June 13, 2018)

iDose-Travoprost for Glaucoma (January 10, 2018)

Rhopressa for Glaucoma (October 13, 2017)

Rhopressa for Glaucoma (October 11, 2017)

INO-8875 for Glaucoma (July 7, 2017)

Trabodenoson/Latanoprost FDC for Glaucoma (July 7, 2017)

KEY UPCOMING EVENTS

KEY REGULATORY EVENTS

Ocumension Gets Certain Asian Rights To NicOx’s Glaucoma Compound

Xelpros Approval Adds Spark To Sun’s Site Too?

PROBABILITY OF SUCCESS

LICENSING AND ASSET ACQUISITION DEALS

Astellas Buys UK Eye Gene Therapy Firm

Q BioMed, Washington Univ. Team Up In Glaucoma

PARENT PATENTS

REVENUE OPPORTUNITY

CLINICAL TRIAL LANDSCAPE

Sponsors by status

Sponsors by phase

Recent events

BIBLIOGRAPHY

Prescription information

APPENDIX

For more information about this report visit https://www.researchandmarkets.com/r/nkassk

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Related
Topics: Optical

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