Chronic Spontaneous Urticaria (CSU) in 7 Major Markets: Insights, Epidemiology and Forecast to 2030 – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “Chronic Spontaneous Urticaria (CSU) – Market Insights, Epidemiology, and Market Forecast – 2030” drug pipelines has been added to ResearchAndMarkets.com’s offering.

This report delivers an in-depth understanding of the Chronic spontaneous urticaria (CSU), historical and forecasted epidemiology as well as the market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

The report provides current treatment practices, emerging drugs and their market share of the individual therapies, current and forecasted Chronic spontaneous urticaria (CSU) symptoms market size from 2017 to 2030 segmented by seven major markets.

The study also covers current Chronic spontaneous urticaria (CSU) symptoms treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.


The Chronic spontaneous urticaria (CSU) symptoms epidemiology division provides insights about the historical and current patient pool along with the forecasted trend for every seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings

The diagnosed prevalent cases of Chronic spontaneous urticaria (CSU) is increasing in 7MM during the study period, i.e., 2017-2030.

The disease epidemiology covered in the report provides historical as well as forecasted Chronic spontaneous urticaria (CSU) symptoms epidemiology segmented as the Total Prevalent cases of Chronic spontaneous urticaria (CSU), Gender-Specific cases of Chronic spontaneous urticaria (CSU), Age-Specific cases of Chronic spontaneous urticaria (CSU). (Read more…) The report includes the prevalent scenario of Chronic spontaneous urticaria (CSU) symptoms in 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2017 to 2030.

Country-wise Epidemiology

The epidemiology segment also provides the Chronic spontaneous urticaria (CSU) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. The total prevalent cases of Chronic spontaneous urticaria (CSU) associated in 7MM countries was 1,169,632 in 2017.

Drug Chapters

The drug chapter segment of the Chronic spontaneous urticaria (CSU) report encloses the detailed analysis of Chronic spontaneous urticaria (CSU) marketed drugs and early stage (Phase-I, II, III) pipeline drugs. It also helps to understand the Chronic spontaneous urticaria (CSU) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases.

Emerging Drugs

Dupilumab: Sanofi/Regeneron

Dupilumab (DUPIXENT) is a human monoclonal IgG4 antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4R subunit shared by the IL-4 and IL-13 receptor complexes. Dupilumab inhibits IL-4 signaling via the Type I’ receptor and both IL-4 and IL-13 signaling through the Type II’ receptor. Multiple cell types that express IL-4R (e.g., mast cells, eosinophils, macrophages, lymphocytes, epithelial cells, goblet cells) and inflammatory mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines, chemokines) are involved in inflammation. Blocking IL4R with dupilumab inhibits IL-4 and IL-13 cytokine-induced inflammatory responses, including the release of proinflammatory cytokines, chemokines, nitric oxide, and IgE.

Ligelizumab: Novartis Pharmaceuticals

Ligelizumab (QGE031) is a new high-affinity humanized monoclonal anti-IgE antibody that has previously shown dose-dependent and time-dependent suppression of free IgE, basophil FcRI, basophil surface IgE, and skin-prick test responses to an allergen that was superior in extent and duration to that observed with omalizumab and aims to become first-choice biologic after antihistamine therapy.

Market Outlook

The Chronic spontaneous urticaria (CSU) market outlook of the report helps to build the detailed comprehension of the historic, current and forecasted Chronic spontaneous urticaria (CSU) market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology.

This segment gives a thorough detail of Chronic spontaneous urticaria (CSU) market trend of each marketed drug and early-stage pipeline therapy by evaluating their impact based on annual cost of therapy, inclusion and exclusion criteria’s, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to the report, Chronic spontaneous urticaria (CSU) market in 7MM is expected to grow in the study period 2017-2030.

In the United States, Joint Task Force on Practice Parameters (JTFPP) had released treatment guidelines for CSU in 2014 that recommended a stepwise management plan to help alleviate the symptoms of CSU. The first line of treatment includes monotherapy with a second-generation H1-antihistamine. If symptoms persist, a practitioner has one of several options for the 2nd line of treatment. The recommended steps include a four-fold increase in second-generation H1-antihistamine dose, the addition of an alternative second-generation H1-antihistamine, the addition of an H2-antihistamine, addition of a leukotriene receptor antagonist (LTRA), or addition of a first-generation H1-antihistamine. If the symptoms don’t alleviate, the practitioner can prescribe a dose advancement of a potent antihistamine (i.e., doxepin or hydroxyzine). For those with recalcitrant disease, the organization recommends the use of Omalizumab, cyclosporine, or an alternative immunosuppressant.

Several drugs are currently in use for the treatment of chronic urticaria with evidence ranging from randomized, double-blind placebo-controlled clinical investigations to anecdotal case reports. It, therefore, becomes imperative to understand the mechanism of action of these drugs for any upcoming player in the industry.

Key Findings

This section includes a glimpse of the Chronic spontaneous urticaria (CSU) market in 7MM. The market size of Chronic spontaneous urticaria (CSU) in the seven major markets was found to be USD 1,073.3 million in 2017.

Drugs Uptake

This section focuses on the rate of uptake of the potential drugs recently launched or expected to get launched in the market during the study period 2017-2030. The analysis covers Chronic spontaneous urticaria (CSU) market uptake by drugs; patient uptake by therapies; and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allow the comparison of the drugs on the basis of market share and size which again will be useful in investigating factors important in the market uptake and in making financial and regulatory decisions.

Pipeline & Development Activities

The report provides insights into the therapeutic candidate in Phase I, II and III stage. It also analyses Chronic spontaneous urticaria (CSU) key players involved in developing targeted therapeutics. Major players include Sanofi/Regenron, Novartis, AstraZeneca, and others. The report covers the detailed information of collaborations, acquisition, and merger, licensing and patent details for Chronic spontaneous urticaria (CSU) emerging therapies.

Reimbursement Scenario

Approaching reimbursement proactively can have a positive impact both during the early stages of product development and well after product launch. In the report, we take reimbursement into consideration to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.

Xolair (Omalizumab) is approved for the treatment of antihistamine-resistant chronic spontaneous urticaria (CSU) in over 80 countries around the world. It is licensed by the European Medicines Agency of the European Union and the Food and Drug Administration of the USA. However, if the healthcare systems do not provide reimbursement in the countries where it is licensed, its accessibility for treatment is precluded by its relatively high cost. An argument of the health authorities to keep it off reimbursement lists is that CU is not a fatal disease and the regulators in countries with limited financial resources do not attach to omalizumab enough weight to override the reimbursement threshold. However, the presence of angioedema imparts to CU a higher level of importance, as the general public perceives the condition as life-threatening. Although omalizumab provides an effective treatment for CU patients with angioedema, it is all too often not available to them because of the failure of health authorities to reimburse it.

Moreover, 93% of Xolair syringe cost is covered by Medicare part D and Medicare Advantage plan. The same program covers 100% of the cost of Xolair vial. It also covers costs under Part B (Medical Insurance), which helps cover the costs of outpatient care and services. If Xolair is administered during hospital admittance or while being cared for in a skilled nursing facility, Medicare Part A would be billed first, and patients who have a Medicare Advantage plan would also receive the same Part A and Part B coverage. Still, these MA enrollees may also have additional coverage.

KOL Views

To keep up with current market trends, we take KOLs and SME’s opinion working in Chronic spontaneous urticaria (CSU) domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps to understand and validate current and emerging therapies treatment patterns or Chronic spontaneous urticaria (CSU) market trend. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the market and the unmet needs.

Competitive Intelligence Analysis

The publisher performs Competitive and Market Intelligence analysis of the Chronic spontaneous urticaria (CSU) Market by using various Competitive Intelligence tools that includes – SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report

  • The report covers the descriptive overview of Chronic spontaneous urticaria (CSU), explaining its causes, signs and symptoms, physiology and currently available therapies
  • Comprehensive insight has been provided into the Chronic spontaneous urticaria (CSU) epidemiology and treatment in the 7MM
  • Additionally, an all-inclusive account of both the current and emerging therapies for Chronic spontaneous urticaria (CSU) is provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape
  • A detailed review of Chronic spontaneous urticaria (CSU) market; historical and forecasted is included in the report, covering drug outreach in the 7MM
  • The report provides an edge while developing business strategies, by understanding trends shaping and driving the global Chronic spontaneous urticaria (CSU) market

Report Highlights

  • In the coming years, Chronic spontaneous urticaria (CSU) market is set to change due to the rising awareness of the disease, and Favorable Environment for New Anti-infective Modalities; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market
  • The companies and academics are working to assess challenges and seek opportunities that could influence Chronic spontaneous urticaria (CSU) R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition
  • Major players are involved in developing therapies for Chronic spontaneous urticaria (CSU). Launch of emerging therapies will significantly impact the Chronic spontaneous urticaria (CSU) market
  • Our in-depth analysis of the pipeline assets across different stages of development (Phase II), different emerging trends and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities

Companies Mentioned

  • Roche/Novartis
  • Sanofi/Regeneron
  • Novartis Pharmaceuticals
  • AstraZeneca
  • Genentech Inc.
  • Kiniksa Pharmaceuticals Ltd.
  • United BioPharma
  • Eli Lilly and Company
  • GlaxoSmithKline
  • Allakos

For more information about this drug pipelines report visit https://www.researchandmarkets.com/r/6wox4y

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Laura Wood, Senior Press Manager

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