Can-Fite Announces Late-Breaking Abstract Presentation on Namodenoson™ Phase II Results at the American Association of Clinical Oncology (ASCO) Annual Meeting

April 10, 2019 Off By BusinessWire
  • Acceptance for late breaking oral presentation underscores the
    oncology community’s interest in Namodenoson as a potential treatment
    for liver cancer
  • Can-Fite now preparing for Phase III study of Namodenoson in
    patients with advanced liver cancer Child Pugh B 7 cirrhosis with Key
    Opinion Leader as Principal Investigator

PETACH TIKVA, Israel–(BUSINESS WIRE)–Can-Fite
BioPharma Ltd
. (NYSE MKT: CANF) (TASE:CFBI), a biotechnology company
with a pipeline of proprietary small molecule drugs that address cancer,
liver and inflammatory diseases, announced today that a late-breaking
abstract detailing results from the Company’s recently completed
multicenter Phase II trial in patients with advanced liver cancer has
been accepted for oral presentation at the late-breaking abstract
session of the 54th Annual Meeting of the American Society of
Clinical Oncology (ASCO). The world’s largest clinical cancer research
meeting, ASCO, will take place from May 31 to June 4, 2019 in Chicago,
Illinois.

The abstract titled: “A phase II, randomized, double-blind,
placebo-controlled trial evaluating efficacy and safety of namodenoson
(CF102), an a3 adenosine receptor agonist (A3AR), as a second-line
treatment in patients with Child-Pugh B (CPB) advanced hepatocellular
carcinoma (HCC)”, will be presented in an oral session by Prof. Salomon
Stemmer, Principal Investigator of the Phase II trial.

Oral Abstract Presentation Details
Date:
Tuesday, June 02, 2019

Time: 8:00 am CDT
Oral
abstract session: Developmental Immunotherapy and Tumor Immunobiology

“We consider ASCO’s acceptance of our late breaking oral presentation a
testament to the compelling data coming out of our recently completed
Phase II study of Namodenoson. We believe this reflects the oncology
community’s assessment that our Phase II Namodenoson trial is a
high-impact study with significant relevance in the treatment of liver
cancer,” stated Can-Fite CEO Pnina Fishman.

Can-Fite is currently designing and planning the protocol for a Phase
III study with the support of the world’s leading oncologists and
regulatory experts including Dr. Josep Llovet, Founder and Director of
the Liver Cancer Program and Full Professor of Medicine at the Mount
Sinai School of Medicine, New York, a key opinion leader who will serve
as the Phase III study’s Principal Investigator.

About Namodenoson

Namodenoson is a small orally bioavailable drug that binds with high
affinity and selectivity to the A3 adenosine receptor (A3AR).
Namodenoson is being evaluated as a second line treatment for
hepatocellular carcinoma, with a recently completed Phase II trial and
planned Phase III trial in this indication. The drug is currently in an
ongoing Phase II trial as a treatment for non-alcoholic fatty liver
disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A3AR is highly
expressed in diseased cells whereas low expression is found in normal
cells. This differential effect accounts for the excellent safety
profile of the drug.

About Can-Fite BioPharma Ltd.

Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI) is an
advanced clinical stage drug development Company with a platform
technology that is designed to address multi-billion dollar markets in
the treatment of cancer, inflammatory disease and sexual dysfunction.
The Company’s lead drug candidate, Piclidenoson, is currently in Phase
III trials for rheumatoid arthritis and psoriasis. Can-Fite’s liver
cancer drug, Namodenoson, recently completed a Phase II trial for
hepatocellular carcinoma (HCC), the most common form of liver cancer,
and is in a Phase II trial for the treatment of non-alcoholic
steatohepatitis (NASH). Namodenoson has been granted Orphan Drug
Designation in the U.S. and Europe and Fast Track Designation as a
second line treatment for HCC by the U.S. Food and Drug Administration.
Namodenoson has also shown proof of concept to potentially treat other
cancers including colon, prostate, and melanoma. CF602, the Company’s
third drug candidate, has shown efficacy in the treatment of erectile
dysfunction in preclinical studies and the Company is investigating
additional compounds, targeting A3AR, for the treatment of sexual
dysfunction. These drugs have an excellent safety profile with
experience in over 1,000 patients in clinical studies to date. For more
information please visit: www.can-fite.com.

Forward-Looking Statements

This press release may contain forward-looking statements, about
Can-Fite’s expectations, beliefs or intentions regarding, among other
things, market risks and uncertainties, its product development efforts,
business, financial condition, results of operations, strategies or
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Forward-looking statements relate to anticipated or expected events,
activities, trends or results as of the date they are made. Because
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where securities values are highly volatile and may be influenced by
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undertake any obligation to publicly update these forward-looking
statements, whether as a result of new information, future events or
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Contacts

Can-Fite BioPharma
Motti Farbstein
[email protected]
+972-3-9241114