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ImaginAb enrolls metastatic cancer patients for second phase testing CD8 T-cell ImmunoPET imaging agent

ImaginAb has enrolled its first patient for the Phase II clinical trial of its lead product, CD8 tracer 89Zr-Df-IAB22M2C, at City of Hope, a Los Angeles County based independent research and treatment center for cancer, diabetes and other life-threatening diseases.

89Zr-Df-IAB22M2C is a first in class imaging agent that visualizes the immune system using non-invasive, whole-body in vivo PET imaging of CD8 T cells. Using its ‘Minibody’ platform, ImaginAb’s technology targets and visualizes CD8+ T-cells to provide highly-specific, quantitative assessment of the immunological status of each cancer lesion within a patient, potentially enabling treatment to be tailored quickly and specifically to the needs of that patient.

Ian Wilson, CEO of ImaginAb, said: “ImaginAb’s goal is to provide target-specific imaging agents to predict, inform, monitor and enable treatment of cancer disease more effectively. We are delighted to have enrolled and imaged our first patient in this ongoing clinical study at City of Hope, a world-class cancer center.”

The company said the trial will enroll metastatic cancer patients and will study the correlation of imaging signals observed using ImaginAb’s CD8 T-cell ImmunoPET imaging agent, standard-of-care scans, and immunohistochemistry analysis of CD8 in biopsied tissues. The trial will also measure changes in CD8+ T-cell distribution before and after immuno-oncology therapies.

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