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2020 Market Spotlight: Thyroid Cancer – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “Market Spotlight: Thyroid Cancer (2020)” report has been added to ResearchAndMarkets.com’s offering.

This Market Spotlight report covers the thyroid cancer market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, key upcoming and regulatory events, probability of success, patent information, a 10-year disease incidence and five-year prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.

Companies Mentioned

  • Bayer
  • Loxo Oncology
  • Novartis
  • Pfizer

Key Takeaways

  • The publisher estimates that in 2017, there were 559,800 incident cases of thyroid cancer worldwide, and expects that number to increase to 612,600 incident cases by 2026.
  • In the same year, there were an estimated 2.0 million five-year prevalent cases of thyroid cancer worldwide, which is expected to increase to 2.2 million cases by 2026.
  • The approved drugs in the thyroid cancer space focus on a wide variety of targets. These drugs are commonly administered via the oral route, with one product being available in an intramuscular formulation.
  • The largest proportion of industry-sponsored drugs in active clinical development for thyroid cancer are in Phase II, with only one drug in the NDA/BLA stage.
  • Therapies in early-to-mid-stage development for thyroid cancer focus on targets such as RET, carcinoembryonic antigen, immune system, tumor necrosis factor-alpha, and ErbB3/HER3. These therapies are administered via the oral, intravenous, and subcutaneous routes.
  • High-impact upcoming events for drugs in the thyroid cancer space comprise topline Phase III trial results for Cometriq, and an estimated PDUFA date as well as a CHMP opinion for selpercatinib.
  • The overall likelihood of approval of a Phase I solid tumors asset is 5.7%, and the average probability a drug advances from Phase III is 41.9%. Drugs, on average, take 9.4 years from Phase I to approval, compared to 9.3 years in the overall oncology space.
  • There have been 14 licensing and asset acquisition deals involving thyroid cancer drugs during 2015-20. The $1,550m exclusive global collaboration signed in November 2017 between Bayer and Loxo Oncology for the development and commercialization of two novel oncology therapies selectively targeting genetic drivers of cancer was the largest deal.
  • The distribution of clinical trials across Phase I-IV indicates that the vast majority of trials for thyroid cancer have been in the early and mid-phases of development, with 91% of trials in Phase I-II, and only 9% in Phase III-IV.
  • The US has a substantial lead in the number of thyroid cancer clinical trials globally. France leads the major European markets, while China has the top spot in Asia.
  • Clinical trial activity in the thyroid cancer space is dominated by completed trials. Pfizer has the highest number of completed clinical trials for thyroid cancer, with 33 trials.
  • Novartis leads industry sponsors with the highest overall number of clinical trials for thyroid cancer, followed by Pfizer.

Key Topics Covered

OVERVIEW

KEY TAKEAWAYS

DISEASE BACKGROUND

  • Subtypes

TREATMENT

  • Surgery
  • Radioactive Iodine (RAI) Therapy
  • Thyroid Hormone Therapy
  • External Beam Radiation Therapy
  • Targeted Therapy

EPIDEMIOLOGY

MARKETED DRUGS

PIPELINE DRUGS

RECENT EVENTS AND ANALYST OPINION

  • Selpercatinib for Thyroid Cancer (September 29, 2019)
  • Pralsetinib for Thyroid Cancer (June 3, 2019)
  • Pralsetinib for Thyroid Cancer (May 15, 2019)

KEY UPCOMING EVENTS

KEY REGULATORY EVENTS

  • Keeping Track: Year-End Submissions Rush Brings Seven Novel Agents To US FDA

PROBABILITY OF SUCCESS

LICENSING AND ASSET ACQUISITION DEALS

PARENT PATENTS

REVENUE OPPORTUNITY

CLINICAL TRIAL LANDSCAPE

  • Sponsors By Status
  • Sponsors By Phase
  • Lilly’s Loxo Bet Pays Off In Thyroid Cancer, A Second Indication For Selpercatinib

BIBLIOGRAPHY

  • Prescription Information

APPENDIX

LIST OF FIGURES

Figure 1: Trends in incident cases of thyroid cancer, 2017-26

Figure 2: Overview of pipeline drugs for thyroid cancer in the US

Figure 3: Pipeline drugs for thyroid cancer, by company

Figure 4: Pipeline drugs for thyroid cancer, by drug type

Figure 5: Pipeline drugs for thyroid cancer, by classification

Figure 6: Selpercatinib for Thyroid Cancer (September 29, 2019): Phase I/II – LIBRETTO-001

Figure 7: Pralsetinib for Thyroid Cancer (June 3, 2019): Phase I/II – ARROW (NSCLC, Thyroid, Solids)

Figure 8: Pralsetinib for Thyroid Cancer (May 15, 2019): Phase I/II – ARROW (NSCLC, Thyroid, Solids)

Figure 9: Key upcoming events in thyroid cancer

Figure 10: Probability of success in the thyroid cancer pipeline

Figure 11: Licensing and asset acquisition deals in thyroid cancer, 2015-20

Figure 12: Parent patents in thyroid cancer

Figure 13: Clinical trials in thyroid cancer

Figure 14: Top 10 drugs for clinical trials in thyroid cancer

Figure 15: Top 10 companies for clinical trials in thyroid cancer

Figure 16: Trial locations in thyroid cancer

Figure 17: Thyroid cancer trials status

Figure 18: Thyroid cancer sponsors, by phase

LIST OF TABLES

Table 1: Incident cases of thyroid cancer, 2017-26

Table 2: Five-year prevalent cases of thyroid cancer, 2017-26

Table 3: Marketed drugs for thyroid cancer

Table 4: Pipeline drugs for thyroid cancer in the US

Table 5: Selpercatinib for Thyroid Cancer (September 29, 2019)

Table 6: Pralsetinib for Thyroid Cancer (June 3, 2019)

Table 7: Pralsetinib for Thyroid Cancer (May 15, 2019)

Table 8: Historical global sales, by drug ($m), 2014-18

Table 9: Forecasted global sales, by drug ($m), 2020-24

For more information about this report visit https://www.researchandmarkets.com/r/n9g4gj

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